DNA / RNA Sequences Protein Sequences

Many scientiic disciplines (e.g., biology, astrophysics, particle physics, earth sciences) are shifting from in vitro to in silico research as more physical processes and natural phenomena are simulated in a computer (in silico) instead of being observed (in vitro). In many of these virtual laboratories, the computations involved are very complex and long lived. Currently, users are required to manually handle almost all aspects of such computations, including their dependability. Not surprisingly, this is a major bottleneck and a signiicant source of inee-ciencies. To address this issue, we have developed BioOpera, an extensible process support management system for virtual laboratories. In this paper, we brieey discuss the architecture and functionality of BioOpera and show how it can be used to eeciently manage long lived complex computations.